Assay Detail
Binding
CHEMBL765222
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Inhibition of RAF kinase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrroles and other heterocycles as inhibitors of p38 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.35 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.43 |
| CHEMBL88486 | — | — | 1 | 6.33 |
| CHEMBL316275 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL88486 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL316275 | — | IC50 | = | 500.0 | nM | 6.30 |