Assay Detail
Binding
CHEMBL765226
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Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.36 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69929 | — | — | 1 | 7.70 |
| CHEMBL304624 | — | — | 1 | 7.64 |
| CHEMBL430419 | — | — | 1 | 7.25 |
| CHEMBL69764 | — | — | 1 | 7.10 |
| CHEMBL307340 | — | — | 1 | 7.07 |
| CHEMBL401695 | — | — | 1 | 7.05 |
| CHEMBL67874 | — | — | 1 | 6.96 |
| CHEMBL69331 | — | — | 1 | 6.87 |
| CHEMBL305023 | — | — | 1 | 6.68 |
| CHEMBL69228 | — | — | 1 | 6.42 |
| CHEMBL68215 | — | — | 1 | 6.41 |
| CHEMBL71403 | — | — | 1 | 6.24 |
| CHEMBL404842 | — | — | 1 | 6.21 |
| CHEMBL302728 | — | — | 1 | 6.12 |
| CHEMBL402426 | — | — | 1 | 6.02 |
| CHEMBL68572 | — | — | 1 | 6.00 |
| CHEMBL63135 | — | — | 1 | 5.89 |
| CHEMBL304166 | — | — | 1 | 5.85 |
| CHEMBL70286 | — | — | 1 | 5.80 |
| CHEMBL67633 | — | — | 1 | 5.68 |
| CHEMBL71987 | — | — | 1 | 5.60 |
| CHEMBL71955 | — | — | 1 | 5.52 |
| CHEMBL446404 | — | — | 1 | 5.35 |
| CHEMBL302805 | — | — | 1 | 5.30 |
| CHEMBL71922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69929 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL304624 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL430419 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL69764 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL307340 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL401695 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL67874 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL69331 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL305023 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL69228 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL68215 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL71403 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL404842 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL302728 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL402426 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL68572 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL63135 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL304166 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL70286 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL67633 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL71987 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL71955 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL446404 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL302805 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL71922 | — | IC50 | > | 10000.0 | nM | - |