Assay Detail
Binding
CHEMBL765263
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The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1B (CHEMBL2430) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.13 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216520 | — | — | 1 | 8.52 |
| CHEMBL2370706 | — | — | 1 | 8.22 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.22 |
| CHEMBL2370707 | — | — | 1 | 8.22 |
| CHEMBL2370711 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216520 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2370706 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2370707 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2370711 | — | Ki | = | 33.0 | nM | 7.48 |