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Assay Detail

CHEMBL765335

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Functional
Platelet P2T receptor antagonist activity in human platelet assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.
Ingall AH, Dixon J, Bailey A, Coombs ME, Cox D, McInally JI, Hunt SF, Kindon ND, Teobald BJ, Willis PA, Humphries RG, Leff P, Clegg JA, Smith JA, Tomlinson W.
J Med Chem (1999) 42 : 213 -220
PubMed 9925726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 8.54 9.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1160360 1 9.48
CHEMBL1160361 1 9.42
CHEMBL334966 CANGRELOR 4.0 1 9.35
CHEMBL1160364 1 9.14
CHEMBL1160365 1 8.87
CHEMBL336292 1 8.60
CHEMBL1160359 1 8.16
CHEMBL1160363 1 8.02
CHEMBL1160366 1 7.81
CHEMBL1160357 1 6.53
CHEMBL1160356 1 -
CHEMBL1160358 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1160360 IC50 = 0.3311 nM 9.48
CHEMBL1160361 IC50 = 0.3802 nM 9.42
CHEMBL334966 CANGRELOR IC50 = 0.4467 nM 9.35
CHEMBL1160364 IC50 = 0.7244 nM 9.14
CHEMBL1160365 IC50 = 1.349 nM 8.87
CHEMBL336292 IC50 = 2.512 nM 8.60
CHEMBL1160359 IC50 = 6.918 nM 8.16
CHEMBL1160363 IC50 = 9.55 nM 8.02
CHEMBL1160366 IC50 = 15.49 nM 7.81
CHEMBL1160357 IC50 = 295.12 nM 6.53
CHEMBL1160356 IC50 = 316227.77 nM -
CHEMBL1160358 IC50 = 316227.77 nM -