Assay Detail
Binding
CHEMBL765337
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In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.10 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118105 | — | — | 1 | 8.54 |
| CHEMBL299944 | — | — | 1 | 8.49 |
| CHEMBL334115 | — | — | 1 | 8.43 |
| CHEMBL116072 | — | — | 1 | 8.28 |
| CHEMBL325491 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118105 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL299944 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL334115 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL116072 | — | Ki | = | 5.26 | nM | 8.28 |
| CHEMBL325491 | — | Ki | = | 174.0 | nM | 6.76 |