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Assay Detail

CHEMBL765404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity for human PPAR alpha in SPA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor alpha (CHEMBL239)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phenylacetic acid derivatives as hPPAR agonists.
Santini C, Berger GD, Han W, Mosley R, MacNaul K, Berger J, Doebber T, Wu M, Moller DE, Tolman RL, Sahoo SP.
Bioorg Med Chem Lett (2003) 13 : 1277 -1280
PubMed 12657263 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 6.30 7.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278994 L-796449 1 7.27
CHEMBL23874 1 7.00
CHEMBL23296 1 6.51
CHEMBL279053 L-165461 1 6.24
CHEMBL25710 1 6.22
CHEMBL23670 1 5.76
CHEMBL23881 1 5.13
CHEMBL121 ROSIGLITAZONE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278994 L-796449 IC50 = 54.0 nM 7.27
CHEMBL23874 IC50 = 100.0 nM 7.00
CHEMBL23296 IC50 = 310.0 nM 6.51
CHEMBL279053 L-165461 IC50 = 570.0 nM 6.24
CHEMBL25710 IC50 = 600.0 nM 6.22
CHEMBL23670 IC50 = 1730.0 nM 5.76
CHEMBL23881 IC50 = 7400.0 nM 5.13
CHEMBL121 ROSIGLITAZONE IC50 > 5.0 nM -