Assay Detail
Binding
CHEMBL765406
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Inhibitory activity against human Peroxisome proliferator activated receptor alpha
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.02 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344282 | — | — | 1 | 7.92 |
| CHEMBL148639 | — | — | 1 | 7.82 |
| CHEMBL149676 | — | — | 1 | 7.80 |
| CHEMBL345721 | — | — | 1 | 7.72 |
| CHEMBL424133 | LY-518674 | 2.0 | 1 | 7.62 |
| CHEMBL148774 | — | — | 1 | 7.57 |
| CHEMBL278590 | GSK-9578 | — | 1 | 6.92 |
| CHEMBL356170 | — | — | 1 | 6.66 |
| CHEMBL149438 | — | — | 1 | 6.60 |
| CHEMBL147086 | — | — | 1 | 6.02 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344282 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL148639 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL149676 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL345721 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL424133 | LY-518674 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL148774 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL278590 | GSK-9578 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL356170 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL149438 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL147086 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL981 | FENOFIBRIC ACID | IC50 | = | 24000.0 | nM | 4.62 |