Assay Detail
Binding
CHEMBL765412
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Inhibition of bovine heart Phosphodiesterase 1 (PDE1)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85350 | — | — | 1 | 5.47 |
| CHEMBL84731 | — | — | 1 | 5.34 |
| CHEMBL314981 | — | — | 1 | - |
| CHEMBL87304 | — | — | 1 | - |
| CHEMBL89248 | — | — | 1 | - |
| CHEMBL86602 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85350 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL84731 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL314981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL87304 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89248 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86602 | — | IC50 | > | 10000.0 | nM | - |