Assay Detail
Functional
CHEMBL765487
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In vitro antiplasmodial activity against Plasmodium falciparum D10
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.27 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.42 |
| CHEMBL317364 | — | — | 1 | 7.31 |
| CHEMBL98114 | — | — | 1 | 7.09 |
| CHEMBL99254 | — | — | 1 | 7.04 |
| CHEMBL99170 | — | — | 1 | 6.10 |
| CHEMBL44789 | — | — | 1 | 5.42 |
| CHEMBL99921 | — | — | 1 | 5.40 |
| CHEMBL316953 | — | — | 1 | 5.33 |
| CHEMBL31000 | — | — | 1 | 5.29 |
| CHEMBL14474 | QUINOLINE | — | 1 | - |
| CHEMBL319543 | — | — | 1 | - |
| CHEMBL316933 | — | — | 1 | - |
| CHEMBL61236 | — | — | 1 | - |
| CHEMBL99408 | — | — | 1 | - |
| CHEMBL319828 | — | — | 1 | - |
| CHEMBL80298 | — | — | 1 | - |
| CHEMBL100194 | — | — | 1 | - |
| CHEMBL95358 | — | — | 1 | - |
| CHEMBL327761 | — | — | 1 | - |
| CHEMBL99932 | 8-AMINOQUINOLINE | — | 1 | - |
| CHEMBL58146 | QUINOLIN-4-AMINE | — | 1 | - |
| CHEMBL317318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL317364 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL98114 | — | IC50 | = | 80.9 | nM | 7.09 |
| CHEMBL99254 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL99170 | — | IC50 | = | 799.0 | nM | 6.10 |
| CHEMBL44789 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL99921 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL316953 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL31000 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL14474 | QUINOLINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL319543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL316933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL61236 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL319828 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL80298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL100194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL95358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL327761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99932 | 8-AMINOQUINOLINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL58146 | QUINOLIN-4-AMINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL317318 | — | IC50 | > | 10000.0 | nM | - |