Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL765582

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
evaluated for the inhibition of Trypanosoma brucei Phosphoglycerate kinase (PGK)
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma brucei
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphoglycerate kinase (CHEMBL2096677)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH.
J Med Chem (2000) 43 : 4135 -4150
PubMed 11063610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 4.21 4.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL605451 1 4.52
CHEMBL607503 1 4.30
CHEMBL608669 1 4.00
CHEMBL608967 1 4.00
CHEMBL611594 1 -
CHEMBL611309 1 -
CHEMBL610149 1 -
CHEMBL2021381 1 -
CHEMBL255442 1 -
CHEMBL608618 1 -
CHEMBL611858 1 -
CHEMBL609550 1 -
CHEMBL609846 1 -
CHEMBL610380 1 -
CHEMBL609201 1 -
CHEMBL1651369 1 -
CHEMBL609837 1 -
CHEMBL610674 1 -
CHEMBL2113430 1 -
CHEMBL609503 1 -
CHEMBL608076 1 -
CHEMBL610161 1 -
CHEMBL609552 1 -
CHEMBL608082 1 -
CHEMBL610105 1 -
CHEMBL611002 1 -
CHEMBL611009 1 -
CHEMBL388757 N6-BENZYLADENOSINE 1 -
CHEMBL609509 1 -
CHEMBL608959 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL605451 IC50 = 30000.0 nM 4.52
CHEMBL607503 IC50 = 50000.0 nM 4.30
CHEMBL608669 IC50 = 100000.0 nM 4.00
CHEMBL608967 IC50 = 100000.0 nM 4.00
CHEMBL1651369 IC50 = 1500000.0 nM -
CHEMBL128176 IC50 = 1500000.0 nM -
CHEMBL609837 IC50 = 200000.0 nM -
CHEMBL611309 IC50 = 850000.0 nM -
CHEMBL610666 IC50 = 1000000.0 nM -
CHEMBL604202 IC50 = 1500000.0 nM -
CHEMBL610670 IC50 = 1500000.0 nM -
CHEMBL610436 IC50 = 2200000.0 nM -
CHEMBL610955 IC50 = 2500000.0 nM -
CHEMBL610098 IC50 = 4000000.0 nM -
CHEMBL607493 IC50 = 750000.0 nM -
CHEMBL609265 IC50 = 1500000.0 nM -
CHEMBL610959 IC50 = 3000000.0 nM -
CHEMBL404779 IC50 = 3000000.0 nM -
CHEMBL68738 N6-CYCLOPENTYLADENOSINE IC50 = 3900000.0 nM -
CHEMBL609263 IC50 = 3000000.0 nM -
CHEMBL608084 IC50 = 500000.0 nM -
CHEMBL611302 IC50 = 800000.0 nM -
CHEMBL2112337 IC50 = 700000.0 nM -
CHEMBL87357 IC50 = 1800000.0 nM -
CHEMBL609208 IC50 = 2900000.0 nM -
CHEMBL609264 IC50 = 400000.0 nM -
CHEMBL608969 IC50 = 1500000.0 nM -
CHEMBL2113430 IC50 = 3900000.0 nM -
CHEMBL608959 IC50 = 250000.0 nM -
CHEMBL609509 IC50 = 2900000.0 nM -
CHEMBL388757 N6-BENZYLADENOSINE IC50 = 1000000.0 nM -
CHEMBL611009 IC50 = 3000000.0 nM -
CHEMBL611002 IC50 = 3500000.0 nM -
CHEMBL610105 IC50 = 1500000.0 nM -
CHEMBL608082 IC50 = 1400000.0 nM -
CHEMBL609552 IC50 = 500000.0 nM -
CHEMBL610161 IC50 = 1200000.0 nM -
CHEMBL608076 IC50 = 1500000.0 nM -
CHEMBL609503 IC50 = 2000000.0 nM -
CHEMBL609201 IC50 = 1900000.0 nM -
CHEMBL610674 IC50 = 200000.0 nM -
CHEMBL611594 IC50 = 1400000.0 nM -
CHEMBL610149 IC50 = 1900000.0 nM -
CHEMBL2021381 IC50 = 1400000.0 nM -
CHEMBL255442 IC50 = 3500000.0 nM -
CHEMBL608618 IC50 = 1200000.0 nM -
CHEMBL611858 IC50 = 1500000.0 nM -
CHEMBL609550 IC50 = 800000.0 nM -
CHEMBL609846 IC50 = 1400000.0 nM -
CHEMBL610380 IC50 = 1800000.0 nM -