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Assay Detail

CHEMBL765596

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of prolyl 4-hydroxylase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Gallus gallus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Transmembrane prolyl 4-hydroxylase (CHEMBL3047)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel inhibitors of prolyl 4-hydroxylase.
Dowell RI, Hadley EM.
J Med Chem (1992) 35 : 800 -804
PubMed 1312598 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.27 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1744254 1 6.00
CHEMBL166568 1 5.96
CHEMBL1203805 1 5.80
CHEMBL1744252 1 5.75
CHEMBL1203806 1 5.75
CHEMBL1744251 1 5.62
CHEMBL355500 1 5.52
CHEMBL166658 1 5.36
CHEMBL88972 PYRIDINE-2,5-DICARBOXYLIC ACID 1 5.26
CHEMBL1744253 1 5.18
CHEMBL1744255 1 5.07
CHEMBL165469 1 5.02
CHEMBL168009 1 5.02
CHEMBL167156 1 4.97
CHEMBL354853 1 4.77
CHEMBL355886 1 4.57
CHEMBL72628 2-PICOLINIC ACID 1 4.00
CHEMBL167326 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1744254 IC50 = 1000.0 nM 6.00
CHEMBL166568 IC50 = 1100.0 nM 5.96
CHEMBL1203805 IC50 = 1600.0 nM 5.80
CHEMBL1744252 IC50 = 1800.0 nM 5.75
CHEMBL1203806 IC50 = 1800.0 nM 5.75
CHEMBL1744251 IC50 = 2400.0 nM 5.62
CHEMBL355500 IC50 = 3000.0 nM 5.52
CHEMBL166658 IC50 = 4400.0 nM 5.36
CHEMBL88972 PYRIDINE-2,5-DICARBOXYLIC ACID IC50 = 5500.0 nM 5.26
CHEMBL1744253 IC50 = 6600.0 nM 5.18
CHEMBL1744255 IC50 = 8500.0 nM 5.07
CHEMBL165469 IC50 = 9600.0 nM 5.02
CHEMBL168009 IC50 = 9600.0 nM 5.02
CHEMBL167156 IC50 = 10600.0 nM 4.97
CHEMBL354853 IC50 = 17000.0 nM 4.77
CHEMBL355886 IC50 = 27000.0 nM 4.57
CHEMBL72628 2-PICOLINIC ACID IC50 = 100000.0 nM 4.00
CHEMBL167326 IC50 = 500000.0 nM -