Assay Detail
Binding
CHEMBL765597
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Compound was evaluated for the inhibition of prolyl 4-hydroxylase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prolyl 4-hydroxylase subunit alpha-1 (CHEMBL3301) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 5.54 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | — | 1 | 5.29 |
| CHEMBL451545 | — | — | 1 | 4.42 |
| CHEMBL314979 | — | — | 1 | 4.04 |
| CHEMBL314175 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL451545 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL314979 | — | IC50 | = | 90700.0 | nM | 4.04 |
| CHEMBL314175 | — | IC50 | = | 414000.0 | nM | - |