Assay Detail
Binding
CHEMBL765640
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Inhibitory activity against HIV-I protease.
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342947 | — | — | 1 | 8.52 |
| CHEMBL16359 | — | — | 1 | 8.40 |
| CHEMBL138388 | — | — | 1 | 8.26 |
| CHEMBL138637 | — | — | 1 | 8.16 |
| CHEMBL343163 | — | — | 2 | 8.05 |
| CHEMBL343608 | — | — | 1 | 7.96 |
| CHEMBL137832 | — | — | 1 | 7.93 |
| CHEMBL434266 | — | — | 1 | 7.85 |
| CHEMBL335789 | — | — | 1 | 7.62 |
| CHEMBL138135 | — | — | 1 | 7.62 |
| CHEMBL343044 | — | — | 1 | 7.55 |
| CHEMBL138147 | — | — | 1 | 7.52 |
| CHEMBL137977 | — | — | 1 | 7.51 |
| CHEMBL343963 | — | — | 1 | 7.50 |
| CHEMBL337760 | — | — | 1 | 7.48 |
| CHEMBL139519 | — | — | 1 | 7.48 |
| CHEMBL140074 | — | — | 1 | 7.38 |
| CHEMBL336038 | — | — | 1 | 7.37 |
| CHEMBL434808 | — | — | 1 | 7.30 |
| CHEMBL138205 | — | — | 1 | 7.26 |
| CHEMBL344442 | — | — | 1 | 7.24 |
| CHEMBL132747 | — | — | 1 | 7.23 |
| CHEMBL139397 | — | — | 1 | 7.14 |
| CHEMBL16584 | — | — | 1 | 7.02 |
| CHEMBL341707 | — | — | 1 | 6.92 |
| CHEMBL137841 | — | — | 1 | 6.62 |
| CHEMBL139434 | — | — | 1 | 6.58 |
| CHEMBL343811 | — | — | 1 | 6.58 |
| CHEMBL139850 | — | — | 1 | 6.48 |
| CHEMBL436210 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342947 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL16359 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL138388 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL138637 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL343163 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL343608 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL137832 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL434266 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL335789 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL138135 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL343163 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL343044 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL138147 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL137977 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL343963 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL337760 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL139519 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL140074 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL336038 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL434808 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL138205 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL344442 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL132747 | — | Ki | = | 58.3 | nM | 7.23 |
| CHEMBL139397 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL16584 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL341707 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL137841 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL139434 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL343811 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL139850 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL436210 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL139070 | — | Ki | = | 470.0 | nM | 6.33 |