Assay Detail
Binding
CHEMBL765677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4 (phosphodiesterase 4)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.11 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.11 |
| CHEMBL138658 | — | — | 1 | 5.11 |
| CHEMBL422104 | — | — | 1 | - |
| CHEMBL337587 | — | — | 1 | - |
| CHEMBL2110369 | — | — | 1 | - |
| CHEMBL141918 | — | — | 1 | - |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL138658 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL422104 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2110369 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28079 | ZAPRINAST | IC50 | > | 10000.0 | nM | - |