Assay Detail
Binding
CHEMBL765680
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Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.71 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290100 | — | — | 1 | 9.00 |
| CHEMBL43607 | — | — | 1 | 6.96 |
| CHEMBL43570 | — | — | 1 | 6.92 |
| CHEMBL39058 | — | — | 1 | 6.77 |
| CHEMBL296358 | — | — | 1 | 6.54 |
| CHEMBL295994 | — | — | 1 | 6.32 |
| CHEMBL288808 | — | — | 1 | 5.72 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290100 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL43607 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL43570 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL39058 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL296358 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL295994 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL288808 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3500.0 | nM | 5.46 |