Assay Detail
Binding
CHEMBL765685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.31 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.14 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1680.0 | nM | 5.78 |