Assay Detail
Binding
CHEMBL765686
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Inhibition of human neutrophil phosphodiesterase type IV (PDE4)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.47 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84350 | — | — | 1 | 8.70 |
| CHEMBL450274 | — | — | 1 | 7.92 |
| CHEMBL79661 | — | — | 1 | 7.68 |
| CHEMBL82882 | — | — | 1 | 7.60 |
| CHEMBL311025 | — | — | 1 | 7.55 |
| CHEMBL421343 | — | — | 1 | 7.52 |
| CHEMBL83872 | — | — | 1 | 7.52 |
| CHEMBL82934 | — | — | 1 | 7.44 |
| CHEMBL84115 | — | — | 1 | 7.29 |
| CHEMBL70391 | — | — | 1 | 7.28 |
| CHEMBL79739 | — | — | 1 | 7.14 |
| CHEMBL309420 | — | — | 1 | 7.07 |
| CHEMBL81226 | — | — | 1 | 6.95 |
| CHEMBL81020 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84350 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL450274 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL79661 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL82882 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL311025 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL421343 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL83872 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL82934 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL84115 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL70391 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL79739 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL309420 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL81226 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL81020 | — | IC50 | = | 131.0 | nM | 6.88 |