Assay Detail
Binding
CHEMBL765688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against phosphodiesterase 4.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.37 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84350 | — | — | 1 | 8.70 |
| CHEMBL79902 | — | — | 1 | 8.40 |
| CHEMBL74404 | — | — | 1 | 8.00 |
| CHEMBL450274 | — | — | 1 | 7.92 |
| CHEMBL79471 | — | — | 1 | 7.85 |
| CHEMBL309341 | — | — | 1 | 7.72 |
| CHEMBL79661 | — | — | 1 | 7.68 |
| CHEMBL82882 | — | — | 1 | 7.60 |
| CHEMBL311025 | — | — | 1 | 7.55 |
| CHEMBL308407 | — | — | 1 | 7.52 |
| CHEMBL83872 | — | — | 1 | 7.52 |
| CHEMBL419814 | — | — | 1 | 7.52 |
| CHEMBL421343 | — | — | 1 | 7.52 |
| CHEMBL82934 | — | — | 1 | 7.44 |
| CHEMBL310387 | — | — | 1 | 7.43 |
| CHEMBL79535 | — | — | 1 | 7.42 |
| CHEMBL308158 | — | — | 1 | 7.41 |
| CHEMBL72362 | — | — | 1 | 7.38 |
| CHEMBL80107 | — | — | 1 | 7.32 |
| CHEMBL84115 | — | — | 1 | 7.29 |
| CHEMBL70391 | — | — | 1 | 7.28 |
| CHEMBL74631 | — | — | 1 | 7.24 |
| CHEMBL70903 | — | — | 1 | 7.23 |
| CHEMBL79739 | — | — | 1 | 7.14 |
| CHEMBL310612 | — | — | 1 | 7.12 |
| CHEMBL309420 | — | — | 1 | 7.07 |
| CHEMBL312375 | — | — | 1 | 7.03 |
| CHEMBL81226 | — | — | 1 | 6.95 |
| CHEMBL421151 | — | — | 1 | 6.88 |
| CHEMBL312322 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84350 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL79902 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL74404 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL450274 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL79471 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL309341 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL79661 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL82882 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL311025 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL308407 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL83872 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL419814 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL421343 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL82934 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL310387 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL79535 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL308158 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL72362 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL80107 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL84115 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL70391 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL74631 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL70903 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL79739 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL310612 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL309420 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL312375 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL81226 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL421151 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL312322 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL81020 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL79744 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL81180 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL303880 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL81364 | — | IC50 | = | 241.0 | nM | 6.62 |