Assay Detail
Binding
CHEMBL765691
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Inhibition of PDE4 from U937 monocytic cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Orally active PDE4 inhibitors with therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.70 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283443 | — | — | 1 | 9.07 |
| CHEMBL264369 | — | — | 1 | 8.89 |
| CHEMBL27107 | — | — | 1 | 8.05 |
| CHEMBL280611 | — | — | 1 | 8.01 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 8.00 |
| CHEMBL24839 | — | — | 1 | 7.92 |
| CHEMBL27500 | — | — | 1 | 7.58 |
| CHEMBL284867 | — | — | 1 | 7.54 |
| CHEMBL27764 | — | — | 1 | 7.21 |
| CHEMBL26767 | — | — | 1 | 7.21 |
| CHEMBL269289 | — | — | 1 | 7.00 |
| CHEMBL27222 | — | — | 1 | 6.82 |
| CHEMBL27724 | — | — | 1 | 6.80 |
| CHEMBL26993 | — | — | 1 | - |
| CHEMBL26760 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283443 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL264369 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL27107 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL280611 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL24839 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL27500 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL284867 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL27764 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL26767 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL269289 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL27222 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL27724 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL26993 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL26760 | — | IC50 | > | 300.0 | nM | - |