Assay Detail
Binding
CHEMBL765693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291838 | — | — | 1 | 6.32 |
| CHEMBL59408 | — | — | 1 | 5.92 |
| CHEMBL60007 | — | — | 1 | 5.47 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.46 |
| CHEMBL294606 | — | — | 1 | 5.44 |
| CHEMBL60985 | — | — | 1 | 5.43 |
| CHEMBL60060 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291838 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL59408 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL60007 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL294606 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL60985 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL60060 | — | IC50 | = | 7100.0 | nM | 5.15 |