Assay Detail
Binding
CHEMBL765813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The inhibitory activity against cyclooxygenase Prostaglandin G/H synthase 2 (COX-2) measured as PGE-2 production after blood coagulation using human Whole blood assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.57 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147165 | — | — | 1 | 6.40 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 5.89 |
| CHEMBL148542 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147165 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL148542 | — | IC50 | = | 37500.0 | nM | 4.43 |