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Assay Detail

CHEMBL765827

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Binding
Binding affinity towards polyamine transporter on the L1210 cell surface
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type L1210
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter.
Wang C, Delcros JG, Biggerstaff J, Phanstiel O.
J Med Chem (2003) 46 : 2663 -2671
PubMed 12801230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.03 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL545253 1 5.77
CHEMBL540552 1 5.75
CHEMBL544313 1 5.60
CHEMBL33912 1 5.52
CHEMBL33920 1 5.30
CHEMBL554675 1 5.30
CHEMBL543610 1 5.21
CHEMBL284260 1 5.07
CHEMBL441413 1 4.58
CHEMBL37716 1 4.48
CHEMBL539791 1 4.48
CHEMBL92204 1 4.21
CHEMBL33916 1 4.17
CHEMBL30952 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL545253 Ki = 1700.0 nM 5.77
CHEMBL540552 Ki = 1800.0 nM 5.75
CHEMBL544313 Ki = 2500.0 nM 5.60
CHEMBL33912 Ki = 3000.0 nM 5.52
CHEMBL33920 Ki = 5000.0 nM 5.30
CHEMBL554675 Ki = 5000.0 nM 5.30
CHEMBL543610 Ki = 6200.0 nM 5.21
CHEMBL284260 Ki = 8500.0 nM 5.07
CHEMBL441413 Ki = 26000.0 nM 4.58
CHEMBL37716 Ki = 33000.0 nM 4.48
CHEMBL539791 Ki = 33400.0 nM 4.48
CHEMBL92204 Ki = 62300.0 nM 4.21
CHEMBL33916 Ki = 67000.0 nM 4.17
CHEMBL30952 Ki = 125000.0 nM -