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Assay Detail

CHEMBL765915

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HEK293
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostaglandin E2 receptor EP3 subtype (CHEMBL3710)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
Billot X, Chateauneuf A, Chauret N, Denis D, Greig G, Mathieu MC, Metters KM, Slipetz DM, Young RN.
Bioorg Med Chem Lett (2003) 13 : 1129 -1132
PubMed 12643927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.74 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14334 1 6.38
CHEMBL428524 1 6.16
CHEMBL14655 1 5.91
CHEMBL280442 1 5.70
CHEMBL15096 1 5.70
CHEMBL14286 1 5.63
CHEMBL280223 1 5.48
CHEMBL278451 1 4.98
CHEMBL14530 1 -
CHEMBL14439 1 -
CHEMBL275245 1 -
CHEMBL277158 1 -
CHEMBL430121 1 -
CHEMBL14359 1 -
CHEMBL434002 1 -
CHEMBL275667 1 -
CHEMBL1794823 1 -
CHEMBL280247 1 -
CHEMBL430124 1 -
CHEMBL14600 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14334 Ki = 419.0 nM 6.38
CHEMBL428524 Ki = 700.0 nM 6.16
CHEMBL14655 Ki = 1220.0 nM 5.91
CHEMBL280442 Ki = 2014.0 nM 5.70
CHEMBL15096 Ki = 2000.0 nM 5.70
CHEMBL14286 Ki = 2315.0 nM 5.63
CHEMBL280223 Ki = 3340.0 nM 5.48
CHEMBL278451 Ki = 10560.0 nM 4.98
CHEMBL14530 Ki > 13000.0 nM -
CHEMBL14439 Ki > 13000.0 nM -
CHEMBL275245 Ki > 13000.0 nM -
CHEMBL277158 Ki > 13000.0 nM -
CHEMBL430121 Ki > 13000.0 nM -
CHEMBL14359 Ki > 13000.0 nM -
CHEMBL434002 Ki > 13000.0 nM -
CHEMBL275667 Ki > 13000.0 nM -
CHEMBL1794823 Ki > 13000.0 nM -
CHEMBL280247 Ki > 13000.0 nM -
CHEMBL430124 Ki > 13000.0 nM -
CHEMBL14600 Ki > 13000.0 nM -