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Assay Detail

CHEMBL765918

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin F2-alpha receptor (CHEMBL1987)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.
deLong MA, Amburgey J, Taylor C, Wos JA, Soper DL, Wang Y, Hicks R.
Bioorg Med Chem Lett (2000) 10 : 1519 -1522
PubMed 10915040 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 8.03 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36041 1 8.05
CHEMBL2220404 CLOPROSTENOL 2.0 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36041 EC50 = 9.0 nM 8.05
CHEMBL2220404 CLOPROSTENOL EC50 = 10.0 nM 8.00