Assay Detail
Binding
CHEMBL765998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% Inhibition of activity against Yersinia Protein-tyrosine phosphatase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Yersinia |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase C (CHEMBL3243) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.60 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129681 | — | — | 1 | 6.16 |
| CHEMBL338073 | — | — | 1 | 5.77 |
| CHEMBL128936 | — | — | 1 | 5.39 |
| CHEMBL341233 | — | — | 1 | 5.07 |
| CHEMBL129918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129681 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL338073 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL128936 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL341233 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL129918 | — | IC50 | = | 200000.0 | nM | - |