Assay Detail
Binding
CHEMBL766083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human Peroxisome proliferator activated receptor alpha using scintillation proximity assay
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.19 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321634 | — | — | 1 | 7.14 |
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 6.31 |
| CHEMBL104850 | — | — | 2 | 6.25 |
| CHEMBL106666 | GW7845 | — | 1 | 5.96 |
| CHEMBL104494 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321634 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL107367 | FARGLITAZAR | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL104850 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL106666 | GW7845 | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL104494 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL104850 | — | Ki | = | 2600.0 | nM | 5.58 |