Assay Detail
Binding
CHEMBL766084
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Binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) was determined by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.28 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430894 | — | — | 1 | 8.00 |
| CHEMBL324856 | — | — | 1 | 7.85 |
| CHEMBL323773 | — | — | 1 | 7.82 |
| CHEMBL421602 | — | — | 1 | 7.72 |
| CHEMBL110295 | — | — | 1 | 7.64 |
| CHEMBL110408 | — | — | 1 | 7.55 |
| CHEMBL110353 | — | — | 1 | 7.43 |
| CHEMBL326015 | — | — | 1 | 7.10 |
| CHEMBL319637 | — | — | 1 | 6.79 |
| CHEMBL106256 | — | — | 1 | 6.09 |
| CHEMBL109161 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430894 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL324856 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL323773 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL421602 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL110295 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL110408 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL110353 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL326015 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL319637 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL106256 | — | Ki | = | 804.0 | nM | 6.09 |
| CHEMBL109161 | — | Ki | = | 836.0 | nM | 6.08 |