Assay Detail
Binding
CHEMBL766277
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Inhibition of crude bovine cardiac phosphodiesterase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.29 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165705 | — | — | 1 | 4.46 |
| CHEMBL17125 | PELRINONE | 2.0 | 1 | 4.12 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165705 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL17125 | PELRINONE | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL189 | MILRINONE | IC50 | = | 192000.0 | nM | - |