Assay Detail
Binding
CHEMBL766360
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Inhibition of Protein kinase C epsilon
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.89 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.92 |
| CHEMBL103055 | — | — | 1 | 7.12 |
| CHEMBL106384 | — | — | 1 | 7.10 |
| CHEMBL103628 | — | — | 1 | 6.77 |
| CHEMBL106061 | — | — | 1 | 6.60 |
| CHEMBL103506 | — | — | 1 | 6.51 |
| CHEMBL105477 | — | — | 1 | 6.21 |
| CHEMBL321315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL103055 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL106384 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL103628 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL106061 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL103506 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL105477 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL321315 | — | IC50 | - | nM | - |