Assay Detail
Binding
CHEMBL766370
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Inhibition of PKA (protein kinase A)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.06 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296682 | MERIDIANIN E | — | 1 | 7.05 |
| CHEMBL44545 | MERIDIANIN B | — | 1 | 6.68 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | 6.16 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 6.00 |
| CHEMBL296271 | — | — | 1 | 5.50 |
| CHEMBL50498 | MERIDIANIN A | — | 1 | 4.96 |
| CHEMBL50226 | — | — | 1 | - |
| CHEMBL48081 | — | — | 1 | - |
| CHEMBL48082 | — | — | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296682 | MERIDIANIN E | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL44545 | MERIDIANIN B | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL296271 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL50498 | MERIDIANIN A | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL50226 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL48081 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL48082 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL14762 | SELICICLIB | IC50 | > | 1000000.0 | nM | - |