Assay Detail
Binding
CHEMBL766521
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Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.36 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24396 | — | — | 1 | 6.21 |
| CHEMBL23458 | — | — | 1 | 6.16 |
| CHEMBL25773 | — | — | 1 | 6.10 |
| CHEMBL430718 | — | — | 1 | 5.85 |
| CHEMBL24547 | — | — | 1 | 5.77 |
| CHEMBL24548 | — | — | 1 | 5.75 |
| CHEMBL24541 | — | — | 1 | 5.57 |
| CHEMBL24069 | — | — | 1 | 5.51 |
| CHEMBL24602 | — | — | 1 | 5.50 |
| CHEMBL23283 | — | — | 1 | 5.46 |
| CHEMBL283866 | — | — | 1 | 5.24 |
| CHEMBL280861 | — | — | 1 | 5.22 |
| CHEMBL24489 | — | — | 1 | 5.10 |
| CHEMBL23164 | — | — | 1 | 5.10 |
| CHEMBL280862 | — | — | 1 | 5.10 |
| CHEMBL278785 | — | — | 1 | 5.07 |
| CHEMBL278580 | — | — | 1 | 5.07 |
| CHEMBL279214 | — | — | 1 | 5.04 |
| CHEMBL26052 | — | — | 1 | 4.96 |
| CHEMBL283833 | — | — | 1 | 4.96 |
| CHEMBL280721 | — | — | 1 | 4.82 |
| CHEMBL276969 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24396 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL23458 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL25773 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL430718 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL24547 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL24548 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL24541 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL24069 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL24602 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL23283 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL283866 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL280861 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL24489 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL23164 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL280862 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL278785 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL278580 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL279214 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL26052 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL283833 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL280721 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL276969 | — | IC50 | = | 53000.0 | nM | 4.28 |