Assay Detail
Binding
CHEMBL766548
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Inhibition of protein kinase C (PKC) isozyme
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Indolocarbazoles.3. Synthesis of novel aza analogs of staurosporine and K 252a as PKC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.97 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.10 |
| CHEMBL147986 | — | — | 1 | 7.55 |
| CHEMBL421947 | — | — | 1 | 7.30 |
| CHEMBL281948 | K-252A | — | 1 | 7.22 |
| CHEMBL146564 | — | — | 1 | 7.16 |
| CHEMBL357602 | — | — | 1 | 6.64 |
| CHEMBL342767 | — | — | 1 | 6.60 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.26 |
| CHEMBL358130 | — | — | 1 | 5.92 |
| CHEMBL429225 | — | — | 1 | - |
| CHEMBL358314 | — | — | 1 | - |
| CHEMBL357892 | — | — | 1 | - |
| CHEMBL144479 | — | — | 1 | - |
| CHEMBL144598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL147986 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL421947 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL281948 | K-252A | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL146564 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL357602 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL342767 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL358130 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL429225 | — | IC50 | ~ | 5000.0 | nM | - |
| CHEMBL358314 | — | IC50 | ~ | 5000.0 | nM | - |
| CHEMBL357892 | — | IC50 | ~ | 5000.0 | nM | - |
| CHEMBL144479 | — | IC50 | ~ | 5000.0 | nM | - |
| CHEMBL144598 | — | IC50 | ~ | 5000.0 | nM | - |