Assay Detail
Binding
CHEMBL766676
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Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.26 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309907 | — | — | 1 | 8.23 |
| CHEMBL81839 | — | — | 1 | 7.96 |
| CHEMBL79460 | — | — | 1 | 7.89 |
| CHEMBL310364 | — | — | 1 | 7.70 |
| CHEMBL124429 | — | — | 1 | 7.64 |
| CHEMBL331949 | — | — | 1 | 7.60 |
| CHEMBL333946 | — | — | 1 | 7.46 |
| CHEMBL299952 | — | — | 1 | 7.33 |
| CHEMBL310202 | — | — | 1 | 7.29 |
| CHEMBL124882 | — | — | 1 | 7.07 |
| CHEMBL126109 | — | — | 1 | 7.01 |
| CHEMBL79132 | — | — | 1 | 6.80 |
| CHEMBL124428 | — | — | 1 | 6.70 |
| CHEMBL125508 | — | — | 1 | 6.21 |
| CHEMBL324839 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309907 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL81839 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL79460 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL310364 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL124429 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL331949 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL333946 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL299952 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL310202 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL124882 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL126109 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL79132 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL124428 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL125508 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL324839 | — | IC50 | = | 1000.0 | nM | 6.00 |