Assay Detail
Binding
CHEMBL766689
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Kinetic constant was measured for Protein Methylase II of Leishmania donovani promastigotes using supernatant (S12) fraction
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania donovani |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (CHEMBL4240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Total synthesis of uracil analogues of sinefungin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.30 | 4.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 4.33 |
| CHEMBL2093043 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214186 | SINEFUNGIN | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL2093043 | — | Ki | = | 54000.0 | nM | 4.27 |