Assay Detail
Binding
CHEMBL766692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (CHEMBL4763) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.01 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280487 | OKADAIC ACID | — | 1 | 10.15 |
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 10.00 |
| CHEMBL430266 | CALYCULIN A | — | 1 | 9.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280487 | OKADAIC ACID | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL430266 | CALYCULIN A | IC50 | = | 0.13 | nM | 9.89 |