Assay Detail
Binding
CHEMBL766696
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Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.30 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | 6.22 |
| CHEMBL2021376 | — | — | 1 | 5.85 |
| CHEMBL219568 | GUANINE | 3.0 | 1 | 5.30 |
| CHEMBL61868 | — | — | 1 | 5.00 |
| CHEMBL31882 | DEZAGUANINE | 2.0 | 1 | 4.11 |
| CHEMBL3245950 | — | — | 1 | - |
| CHEMBL3144008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8040 | 8-AMINOGUANINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2021376 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL219568 | GUANINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL61868 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL31882 | DEZAGUANINE | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL3245950 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3144008 | — | IC50 | = | 102000.0 | nM | - |