Assay Detail
Binding
CHEMBL766698
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Inhibitory activity against Purine nucleoside phosphorylase evaluated by radiochemical assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Urine |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.33 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285627 | — | — | 1 | 6.77 |
| CHEMBL33189 | — | — | 1 | 6.60 |
| CHEMBL8230 | — | — | 1 | 6.33 |
| CHEMBL2021376 | — | — | 1 | 5.85 |
| CHEMBL284608 | — | — | 1 | 5.34 |
| CHEMBL285258 | — | — | 1 | 5.30 |
| CHEMBL32496 | — | — | 1 | 5.28 |
| CHEMBL36178 | — | — | 1 | 5.05 |
| CHEMBL35812 | — | — | 1 | 4.94 |
| CHEMBL33826 | — | — | 1 | 4.87 |
| CHEMBL33416 | — | — | 1 | 4.53 |
| CHEMBL35668 | — | — | 1 | 4.37 |
| CHEMBL285767 | — | — | 1 | 4.02 |
| CHEMBL35798 | — | — | 1 | - |
| CHEMBL32893 | — | — | 1 | - |
| CHEMBL415041 | — | — | 1 | - |
| CHEMBL287608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285627 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL33189 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL8230 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2021376 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL284608 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL285258 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL32496 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL36178 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL35812 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL33826 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL33416 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL35668 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL285767 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL35798 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL32893 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL415041 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL287608 | — | IC50 | = | 131000.0 | nM | - |