Assay Detail
Binding
CHEMBL766710
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Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.32 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267312 | — | — | 1 | 6.68 |
| CHEMBL13130 | — | — | 1 | 5.96 |
| CHEMBL267803 | — | — | 1 | - |
| CHEMBL13159 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267312 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL13130 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL267803 | — | Ki | = | 170.0 | nM | - |
| CHEMBL13159 | — | Ki | = | 110000.0 | nM | - |