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Assay Detail

CHEMBL766723

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition activity against recombinant human Prostaglandin G/H synthase 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
Kolasa T, Brooks CD, Rodriques KE, Summers JB, Dellaria JF, Hulkower KI, Bouska J, Bell RL, Carter GW.
J Med Chem (1997) 40 : 819 -824
PubMed 9057869 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.28 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL521 IBUPROFEN 4.0 1 7.00
CHEMBL6 INDOMETHACIN 4.0 1 6.25
CHEMBL154 NAPROXEN 4.0 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL521 IBUPROFEN IC50 = 100.0 nM 7.00
CHEMBL6 INDOMETHACIN IC50 = 560.0 nM 6.25
CHEMBL154 NAPROXEN IC50 = 2500.0 nM 5.60