Assay Detail
Binding
CHEMBL766724
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Inhibition concentration against cyclooxygenase-2 (COX-2) in human whole blood
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.99 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341320 | — | — | 1 | 7.22 |
| CHEMBL127211 | — | — | 1 | 7.10 |
| CHEMBL125460 | — | — | 1 | 6.82 |
| CHEMBL126303 | — | — | 1 | 6.77 |
| CHEMBL126369 | — | — | 1 | 6.75 |
| CHEMBL129640 | — | — | 1 | 6.75 |
| CHEMBL126991 | — | — | 1 | 6.72 |
| CHEMBL442767 | — | — | 1 | 6.70 |
| CHEMBL127868 | — | — | 1 | 6.68 |
| CHEMBL127153 | — | — | 1 | 6.62 |
| CHEMBL338457 | — | — | 1 | 6.51 |
| CHEMBL420351 | — | — | 1 | 6.50 |
| CHEMBL127514 | — | — | 1 | 6.44 |
| CHEMBL126683 | — | — | 1 | 6.39 |
| CHEMBL127190 | — | — | 1 | 6.17 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.12 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 6.09 |
| CHEMBL127084 | — | — | 1 | 6.01 |
| CHEMBL127125 | — | — | 1 | 6.00 |
| CHEMBL338705 | — | — | 1 | 5.97 |
| CHEMBL126810 | — | — | 1 | 5.95 |
| CHEMBL126404 | — | — | 1 | 5.87 |
| CHEMBL127560 | — | — | 1 | 5.84 |
| CHEMBL338347 | — | — | 1 | 5.83 |
| CHEMBL265071 | — | — | 1 | 5.83 |
| CHEMBL126392 | — | — | 1 | 5.82 |
| CHEMBL338927 | — | — | 1 | 5.76 |
| CHEMBL127268 | — | — | 1 | 5.74 |
| CHEMBL126979 | — | — | 1 | 5.69 |
| CHEMBL126629 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341320 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL127211 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL125460 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL126303 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL126369 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL129640 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL126991 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL442767 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL127868 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL127153 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL338457 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL420351 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL127514 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL126683 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL127190 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL127084 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL127125 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL338705 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL126810 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL126404 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL127560 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL338347 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL265071 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL126392 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL338927 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL127268 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL126979 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL126629 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL126578 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL339258 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL339817 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL125682 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL126244 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL129473 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL127210 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL126364 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL124188 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL339150 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL129613 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL127267 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL129299 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL338371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL339355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340101 | — | IC50 | > | 10000.0 | nM | - |