Assay Detail
Binding
CHEMBL766763
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Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Meleagris gallopavo |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.04 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373948 | — | — | 1 | 9.06 |
| CHEMBL2373323 | — | — | 1 | 8.52 |
| CHEMBL2373389 | — | — | 1 | 8.43 |
| CHEMBL435402 | — | — | 1 | 8.22 |
| CHEMBL2373377 | — | — | 1 | 8.22 |
| CHEMBL336208 | — | — | 1 | 8.10 |
| CHEMBL302077 | — | — | 1 | 7.85 |
| CHEMBL2373946 | — | — | 1 | 7.44 |
| CHEMBL2373324 | — | — | 1 | 7.04 |
| CHEMBL1368696 | — | — | 1 | 6.14 |
| CHEMBL2373947 | — | — | 1 | 5.92 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 5.55 |
| CHEMBL2373945 | — | — | 1 | 5.41 |
| CHEMBL2373325 | — | — | 1 | 4.95 |
| CHEMBL1199042 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373948 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL2373323 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2373389 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL435402 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2373377 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL336208 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL302077 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2373946 | — | EC50 | = | 36.6 | nM | 7.44 |
| CHEMBL2373324 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1368696 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2373947 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2373945 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2373325 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1199042 | — | EC50 | = | 19000.0 | nM | 4.72 |