Assay Detail
Binding
CHEMBL766796
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Inhibition of HIV -1 protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.86 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138267 | — | — | 1 | 6.46 |
| CHEMBL141281 | — | — | 1 | 6.43 |
| CHEMBL3138268 | — | — | 1 | 6.41 |
| CHEMBL3137943 | — | — | 1 | 5.82 |
| CHEMBL3138187 | — | — | 1 | 5.82 |
| CHEMBL113197 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138267 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL141281 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3138268 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3137943 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3138187 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL113197 | — | IC50 | = | 58000.0 | nM | 4.24 |