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Assay Detail

CHEMBL766820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-KI
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin F2-alpha receptor (CHEMBL1987)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.
deLong MA, Amburgey J, Taylor C, Wos JA, Soper DL, Wang Y, Hicks R.
Bioorg Med Chem Lett (2000) 10 : 1519 -1522
PubMed 10915040 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.39 8.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39784 1 8.07
CHEMBL289568 1 7.38
CHEMBL289373 1 7.12
CHEMBL290969 1 7.09
CHEMBL36911 1 6.68
CHEMBL286132 1 6.68
CHEMBL416784 1 6.54
CHEMBL36901 1 6.27
CHEMBL37244 1 6.20
CHEMBL35715 1 5.79
CHEMBL288277 1 5.67
CHEMBL289660 1 5.44
CHEMBL290571 1 5.36
CHEMBL39746 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39784 IC50 = 8.6 nM 8.07
CHEMBL289568 IC50 = 42.0 nM 7.38
CHEMBL289373 IC50 = 76.0 nM 7.12
CHEMBL290969 IC50 = 82.0 nM 7.09
CHEMBL36911 IC50 = 210.0 nM 6.68
CHEMBL286132 IC50 = 210.0 nM 6.68
CHEMBL416784 IC50 = 290.0 nM 6.54
CHEMBL36901 IC50 = 540.0 nM 6.27
CHEMBL37244 IC50 = 630.0 nM 6.20
CHEMBL35715 IC50 = 1620.0 nM 5.79
CHEMBL288277 IC50 = 2140.0 nM 5.67
CHEMBL289660 IC50 = 3630.0 nM 5.44
CHEMBL290571 IC50 = 4400.0 nM 5.36
CHEMBL39746 IC50 = 5890.0 nM 5.23