Assay Detail
Binding
CHEMBL766844
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In vitro inhibitory activity against protein kinase A
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | unidentified |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Identification of tricyclic analogs related to ellagic acid as potent/selective tyrosine protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.97 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71144 | — | — | 1 | 6.30 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 6.22 |
| CHEMBL304361 | — | — | 1 | 6.00 |
| CHEMBL69174 | — | — | 1 | 5.82 |
| CHEMBL72338 | — | — | 1 | 5.64 |
| CHEMBL304362 | — | — | 1 | 5.50 |
| CHEMBL302981 | — | — | 1 | 5.40 |
| CHEMBL308175 | — | — | 1 | 5.38 |
| CHEMBL304808 | — | — | 1 | 5.18 |
| CHEMBL71002 | — | — | 1 | 5.16 |
| CHEMBL305234 | — | — | 1 | 5.08 |
| CHEMBL422771 | — | — | 1 | 5.00 |
| CHEMBL70346 | — | — | 1 | 4.77 |
| CHEMBL69237 | — | — | 1 | 4.70 |
| CHEMBL73937 | — | — | 1 | 4.64 |
| CHEMBL305223 | — | — | 1 | 4.40 |
| CHEMBL73721 | — | — | 1 | 4.40 |
| CHEMBL69240 | — | — | 1 | 4.33 |
| CHEMBL308112 | — | — | 1 | 4.30 |
| CHEMBL72035 | — | — | 1 | 4.30 |
| CHEMBL302472 | — | — | 1 | 4.29 |
| CHEMBL70659 | — | — | 1 | 4.24 |
| CHEMBL421872 | — | — | 1 | 4.11 |
| CHEMBL302483 | — | — | 1 | 4.04 |
| CHEMBL70750 | — | — | 1 | - |
| CHEMBL71205 | — | — | 1 | - |
| CHEMBL70413 | — | — | 1 | - |
| CHEMBL305966 | — | — | 1 | - |
| CHEMBL266154 | — | — | 1 | - |
| CHEMBL304983 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71144 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL304361 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL69174 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL72338 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL304362 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL302981 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL308175 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL304808 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL71002 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL305234 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL422771 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL70346 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL69237 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL73937 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL305223 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL73721 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL69240 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL308112 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL72035 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL302472 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL70659 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL421872 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL302483 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL302325 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL71210 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL72682 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL305794 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL70360 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL307112 | — | IC50 | = | 415000.0 | nM | - |
| CHEMBL306785 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL308311 | — | IC50 | = | 223000.0 | nM | - |
| CHEMBL71206 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL70942 | — | IC50 | = | 284000.0 | nM | - |
| CHEMBL308438 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL306019 | — | IC50 | = | 275000.0 | nM | - |
| CHEMBL70594 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL305621 | — | IC50 | = | 317000.0 | nM | - |
| CHEMBL302824 | — | IC50 | = | 634000.0 | nM | - |
| CHEMBL304983 | — | IC50 | = | 435000.0 | nM | - |
| CHEMBL266154 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL305966 | — | IC50 | = | 374000.0 | nM | - |
| CHEMBL70413 | — | IC50 | = | 541000.0 | nM | - |
| CHEMBL71205 | — | IC50 | = | 309000.0 | nM | - |
| CHEMBL70750 | — | IC50 | = | 115000.0 | nM | - |