Assay Detail
Functional
CHEMBL767003
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In vitro antimalarial activity for Plasmodium falciparum BHz26/86
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.86 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.70 |
| CHEMBL278722 | — | — | 1 | 5.76 |
| CHEMBL15160 | — | — | 1 | 5.72 |
| CHEMBL15688 | — | — | 1 | 5.64 |
| CHEMBL280012 | — | — | 1 | 5.50 |
| CHEMBL15321 | — | — | 1 | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | — | 1 | - |
| CHEMBL14910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL278722 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL15160 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL15688 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL280012 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL15321 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL14910 | — | IC50 | > | 20000.0 | nM | - |