Assay Detail
Functional
CHEMBL767004
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In vitro antimalarial activity for Plasmodium falciparum D6
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.10 |
| CHEMBL278722 | — | — | 1 | 5.61 |
| CHEMBL280012 | — | — | 1 | 5.43 |
| CHEMBL15160 | — | — | 1 | 5.39 |
| CHEMBL15688 | — | — | 1 | 5.37 |
| CHEMBL15321 | — | — | 1 | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | — | 1 | - |
| CHEMBL14910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL278722 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL280012 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL15160 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL15688 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL15321 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL14910 | — | IC50 | > | 20000.0 | nM | - |