Assay Detail
Functional
CHEMBL767005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antimalarial activity for Plasmodium falciparum W2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.73 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.40 |
| CHEMBL278722 | — | — | 1 | 5.78 |
| CHEMBL15160 | — | — | 1 | 5.52 |
| CHEMBL15688 | — | — | 1 | 5.49 |
| CHEMBL280012 | — | — | 1 | 5.45 |
| CHEMBL15321 | — | — | 1 | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | — | 1 | - |
| CHEMBL14910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL278722 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL15160 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL15688 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL280012 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL15321 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL15365 | BENZO[A]PHENAZINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL14910 | — | IC50 | > | 20000.0 | nM | - |