Assay Detail
Functional
CHEMBL767019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory concentration against HIV-2 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 2 pol protein (CHEMBL5074) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 2 |
Publication
Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.95 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310924 | — | — | 1 | 9.74 |
| CHEMBL17612 | — | — | 1 | 9.62 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.30 |
| CHEMBL75082 | — | — | 1 | 8.49 |
| CHEMBL306974 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310924 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL17612 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL75082 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL306974 | — | IC50 | = | 24.9 | nM | 7.60 |