Assay Detail
Binding
CHEMBL767080
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Inhibition of PDE4 from guinea pig macrophages
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL93823 | — | — | 1 | 8.70 |
| CHEMBL330055 | — | — | 1 | 7.64 |
| CHEMBL89931 | — | — | 1 | 7.60 |
| CHEMBL329556 | — | — | 1 | 7.57 |
| CHEMBL449708 | — | — | 1 | 7.38 |
| CHEMBL329155 | — | — | 1 | 7.00 |
| CHEMBL93327 | — | — | 1 | 6.35 |
| CHEMBL329365 | — | — | 1 | 6.27 |
| CHEMBL329023 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL93823 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL330055 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL89931 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL329556 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL449708 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL329155 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL93327 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL329365 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL329023 | — | IC50 | = | 4400.0 | nM | 5.36 |