Assay Detail
Binding
CHEMBL767083
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In vitro inhibition of Phosphodiesterase 4 from guinea pig lung
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.95 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552877 | — | — | 1 | 9.80 |
| CHEMBL12346 | — | — | 1 | 9.70 |
| CHEMBL552876 | — | — | 1 | 9.31 |
| CHEMBL536801 | — | — | 1 | 9.26 |
| CHEMBL536568 | — | — | 1 | 9.20 |
| CHEMBL12412 | — | — | 1 | 9.17 |
| CHEMBL543016 | — | — | 1 | 9.15 |
| CHEMBL537465 | — | — | 1 | 9.05 |
| CHEMBL12383 | — | — | 1 | 8.55 |
| CHEMBL537252 | — | — | 1 | 7.82 |
| CHEMBL556982 | — | — | 1 | 7.77 |
| CHEMBL543965 | — | — | 1 | 7.52 |
| CHEMBL543017 | — | — | 1 | 7.51 |
| CHEMBL274528 | — | — | 1 | 7.40 |
| CHEMBL536785 | — | — | 1 | 7.40 |
| CHEMBL12599 | — | — | 1 | 7.10 |
| CHEMBL542296 | — | — | 1 | 6.82 |
| CHEMBL556787 | — | — | 1 | 6.72 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.30 |
| CHEMBL543491 | — | — | 1 | 6.16 |
| CHEMBL553539 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552877 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL12346 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL552876 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL536801 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL536568 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL12412 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL543016 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL537465 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL12383 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL537252 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL556982 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL543965 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL543017 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL274528 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL536785 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL12599 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL542296 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL556787 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL543491 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL553539 | — | IC50 | = | 5000.0 | nM | 5.30 |